Akademik Veri Yönetim Sistemi
Osmangazi Tıp Dergisi, cilt.48, sa.3, ss.508-513, 2026 (TRDizin)
Immature granulocytes (IGs) have been widely used as biomarker in systemic inflammation. Diabetic ketoacidosis (DKA) is a condition characterized by systemic inflammation. We aimed to evaluate the relationship between IG count (IGC) and IG percentage (%IG) and severity of DKA in children. We evaluated the data of the patients with DKA. IGC was calculated using the white cell differential channel of the Sysmex XN 9000. IGC was expressed as the absolute number of IGs per microliter (IGCx106/uL), and IG% was determined as percentage of total leukocyte count. The data of 68 patients with DKA were analyzed. IGC and IG% were significantly higher in patients with severe DKA compared with those with mild and moderate DKA (p<0.001 for each). In severe DKA, IGC and IG% had a predictive value (p<0.001, p=0.001, respectively). The area under curve values of IG% and IGC were 0.869±0.048 and 0.875±0.044, respectively. Sixteen patients had a concomitant infection at the admission. No significant differences were observed between patients with and without infection in terms of IGC and IG%. In patients with severe DKA, granulocytosis is accompanied by increased IGC and IG% in the peripheral bloodstream, regardless of the presence of an infection.