Curcumin and LOXblock-1 ameliorate ischemia-reperfusion induced inflammation and acute kidney injury by suppressing the semaphorin-plexin pathway

Kar F., Hacıoğlu C., Şentürk H., Burukoğlu Dönmez D., Kanbak G., Uslu S.

LIFE SCIENCES, vol.256, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 256
  • Publication Date: 2020
  • Doi Number: 10.1016/j.lfs.2020.118016
  • Journal Name: LIFE SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, BIOSIS, CAB Abstracts, Chimica, EMBASE, MEDLINE, Veterinary Science Database
  • Keywords: AKI, Renal I/R, SEMA3A, Curcumin, LOXblock-1, RENAL ISCHEMIAREPERFUSION INJURY, ISCHEMIA/REPERFUSION INJURY, LIVER, ASSAY
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Aims: Ischemia/reperfusion (I/R) is one of the most important causes of acute kidney injury (AKI), a clinical syndrome with kidney dysfunction and high mortality rates. New diagnostic biomarkers need to be defined to better illuminate the pathophysiology of AKI. For the first time, we aim to investigate the protective effects of Curcumin which is known for its antioxidant and anti-inflammatory properties and 12/15 lipoxygenase inhibitor LOXblock-1 on I/R induced AKI by modulating inflammatory processes, oxidative stress, apoptosis and semaphorin-plexin pathway.