IDH2 Mutations in Primary Glioblastoma

Atli E. I., Kalkan R., Ciftci E., Ozkara E., ÇİLİNGİR O., Ozdemir M., ...Daha Fazla

JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH, sa.4, ss.693-698, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2014
  • Dergi Adı: JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.693-698
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Purpose: To establish the frequency of IDH2 mutations in primary glioblastoma at a population level. Experimental Design: We screened primary glioblastoma in a population-based study for IDH2 mutations and correlated them with clinical data. Results: No IDH2 gene mutation was detected in tumor samples. Since the analyzed tumor samples were the primary GBMs, the data of undetected IDH2 gene mutation was in agreement with the literature. Conclusion: In summary, our study is the first study to investigate the IDH2 status in primary GBMs in Turkish patients. Anaplastic astrocytoma or glioblastoma patients with IDH1/IDH2 mutations have been reported to be younger than those carrying the wild-type allele. Accordingly IDH1/IDH2 mutations were observed more frequently in patients at an early age. In our study, mutations were not detected in our study group, thus a statistical ratio cannot be derived. The average age for our patient sample was 54.5 +/- 2.