Cyclophosphamide induced oxidative stress, lipid per oxidation, apoptosis and histopathological changes in rats: Protective role of boron


Cengiz M., Şahintürk V., Yildiz S. C. , Sahin I. K. , Bilici N., Onur Yaman S., ...More

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, vol.62, 2020 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 62
  • Publication Date: 2020
  • Doi Number: 10.1016/j.jtemb.2020.126574
  • Journal Name: JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
  • Journal Indexes: Science Citation Index Expanded, Scopus, BIOSIS, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Keywords: Cyclophosphamide, Testicular damage, Apoptosis, Boron, Anti-Oxidant, Lipid per oxidation, GERM-CELL APOPTOSIS, BORIC-ACID, DIETARY BORON, ELLAGIC ACID, DAMAGE, TOXICITY, GENOTOXICITY, METABOLITES, EXPOSURE, BLOOD

Abstract

Background: Cyclophosphamide (CP) is an alkylating chemotherapeutic drug used in the treatment of many types of cancer. However, as with other chemotherapeutic drugs, the use of CP is limited by the damage to healthy tissues such as testes, bladder and liver as well as cancerous tissue. Boron (B) is a trace element with many biological properties such as antioxidant, anti-apoptotic and anti-lipid per oxidation.