Effects of intrarectal and intraperitoneal N(G)-nitro-L-arginine methyl ester treatment in 2,4,6-trinitrobenzenesulfonic acid induced colitis in rats

Vardareli E., Dundar E., Angin K., Saricam T., Inal M.

EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, cilt.55, sa.4, ss.271-276, 2003 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 55 Sayı: 4
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1078/0940-2993-00324
  • Dergi Adı: EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.271-276
  • Anahtar Kelimeler: nitric oxide, L-NAME, 2,4,6-trinitrobenzenesulfonic acid induced colitis, rats, NITRIC-OXIDE SYNTHASE, INFLAMMATORY-BOWEL-DISEASE, TRINITROBENZENE SULFONIC-ACID, ACTIVE ULCERATIVE-COLITIS, CROHNS-DISEASE, COLONIC MUCOSA, EXPRESSION, INHIBITION, NITROTYROSINE, PEROXYNITRITE
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Inflammatory bowel disease (IBD) has been associated with an increased generation of nitric oxide (NO). Different authors have shown that NO in 1131) can be either harmful or protective. The aim of this study was to investigate the efficiency of intrarectal (IR) and intraperitoneal (IP) application of N(G)-nitro-L-arginine methyl ester (L-NAME), a non-specific nitric oxide synthase inhibitor, in experimental acute colitis in the rats.