Effects of intrarectal and intraperitoneal N(G)-nitro-L-arginine methyl ester treatment in 2,4,6-trinitrobenzenesulfonic acid induced colitis in rats

Vardareli E., Dundar E., Angin K., Saricam T., Inal M.

EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, vol.55, no.4, pp.271-276, 2003 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 55 Issue: 4
  • Publication Date: 2003
  • Doi Number: 10.1078/0940-2993-00324
  • Journal Name: EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.271-276
  • Keywords: nitric oxide, L-NAME, 2,4,6-trinitrobenzenesulfonic acid induced colitis, rats, NITRIC-OXIDE SYNTHASE, INFLAMMATORY-BOWEL-DISEASE, TRINITROBENZENE SULFONIC-ACID, ACTIVE ULCERATIVE-COLITIS, CROHNS-DISEASE, COLONIC MUCOSA, EXPRESSION, INHIBITION, NITROTYROSINE, PEROXYNITRITE
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Inflammatory bowel disease (IBD) has been associated with an increased generation of nitric oxide (NO). Different authors have shown that NO in 1131) can be either harmful or protective. The aim of this study was to investigate the efficiency of intrarectal (IR) and intraperitoneal (IP) application of N(G)-nitro-L-arginine methyl ester (L-NAME), a non-specific nitric oxide synthase inhibitor, in experimental acute colitis in the rats.