EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, cilt.55, sa.4, ss.271-276, 2003 (SCI-Expanded)
Inflammatory bowel disease (IBD) has been associated with an increased generation of nitric oxide (NO). Different authors have shown that NO in 1131) can be either harmful or protective. The aim of this study was to investigate the efficiency of intrarectal (IR) and intraperitoneal (IP) application of N(G)-nitro-L-arginine methyl ester (L-NAME), a non-specific nitric oxide synthase inhibitor, in experimental acute colitis in the rats.