Questioning the adequacy of standardized vitamin D supplementation protocol in very low birth weight infants: a prospective cohort study

Sarıdemir H., Surmeli Onay Ö., Aydemir Ö., Tekin A. N.

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, vol.34, no.12, pp.1515-1523, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 12
  • Publication Date: 2021
  • Doi Number: 10.1515/jpem-2021-0390
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, EMBASE, MEDLINE
  • Page Numbers: pp.1515-1523
  • Keywords: neonatal intensive care unit, preterm, very low birth weight infant, vitamin D, vitamin D supplementation, RESPIRATORY-TRACT INFECTIONS, D DEFICIENCY, PRETERM INFANTS, PREGNANT-WOMEN, RISK-FACTOR, PREVENTION, TRIAL, REQUIREMENTS, ASSOCIATION, CHILDHOOD
  • Eskisehir Osmangazi University Affiliated: Yes


Objectives: Preterm infants are at increased risk for vitamin D deficiency (VDD). We aimed to assess the adequacy of standardized vitamin D supplementation protocol in very low birth weight (VLBW) infants. Additionally, vitamin D status of mother/infant couples and the associations between vitamin D status at birth and morbidities of the infants were investigated. Methods: In this single-center, prospective cohort study blood samples were collected from 55 mothers just before delivery and from their infants at birth and on the 30th day of life (DOL) for 25 hydroxy vitamin D (25OHD) measurements. Vitamin D was initiated in dose of 160 IU/kg by parenteral nutrition on the first DOL and oral vitamin D supplementation (400 IU/day) was administered when enteral feedings reached 50% of total intake or on the 15th DOL. Results: The median 25OHD levels of the infants were 16.12 (9.14-20.50) in cord blood and 36.32 (31.10-44.44) in venous blood on the 30th DOL (p<0.01). In 98% of the VLBW infants 25OHD reached sufficient levels on the 30th DOL. None of the mothers had sufficient vitamin D levels (25OHD >30 ng/mL). Maternal 25OHD levels were correlated with the 25OHD levels of the infants in cord blood (r=0.665, p<0.001). There was a significant difference in mean cord 25OHD levels between winter (13.65 +/- 5.69 ng/mL) and summer seasons (19.58 +/- 11.67 ng/mL) (p=0.021). No association was found between neonatal morbidity and vitamin D status. Conclusions: The results clearly show that by utilizing the current supplementation protocol, the majority of VLBW infants with deficient/insufficient serum 25OHD levels reached sufficient levels on the 30th DOL. Furthermore, vitamin D levels in mother/infant couples were found to be highly correlated.