Akademik Veri Yönetim Sistemi
EUROPEAN RESPIRATORY JOURNAL, cilt.66, sa.69, ss.1, 2025 (SCI-Expanded, SSCI, Scopus)
Abstract
Objective: Inspiratory muscle dysfunction is the main mechanism that reduces exercise capacity in fibrotic interstitial lung disease (FILD). The aim of this study is to investigate the relationship between diaphragmatic ultrasound findings and respiratory mechanics in patients with FILD.
Materials and methods: All patients were evaluated with chest ultrasound for functional evaluation (number of B lines, end-expiratory and end-inspiratory diaphragmatic thickness, diaphragmatic thickness fraction, diaphragmatic excursion in quiet and deep breathing). Respiratory function tests (including diffusion parameters, maximal inspiratory pressure (MIP), maximal expiratory pressure (MEP), body plethysmography) and 6MWT were performed on all patients. In our study, Spearman correlation analysis was used to determine the relationship between variables.
Results: We prospectively included 34 FILD patients (18 women and 16 men, mean age 67.08 ±7.29 years). The mean diaphragmatic thickness fraction was calculated as 43.33 ± 30.16%. Mean diaphragmatic excursion was 1.81 ± 0.88 cm in quite breathing and 3.42 ± 1.64 cm in deep breathing. The mean 6MWT was 421.77 ± 83.18 m, the mean MIP was 45.92 ± 21.61 cmH2O. MIP showed a statistically significant positive correlation with 6MWT (p<0.05). The MIP value was not correlated with diaphragmatic parameters measured by ultrasonography (p>0.05).
Conclusion: This study showed that there was no statistically significant correlation between MIP and diaphragmatic ultrasound in the functional evaluation of FILD patients. However, MIP values are affected by patient effort, so results should be interpreted with caution.