Akademik Veri Yönetim Sistemi
53rd Annual Meeting of European Society for Paediatric Nephrology, Amsterdam, Hollanda, 16 - 19 Eylül 2021, ss.3487-3488
EP-324 DO THE RESISTANCE PATTERNS OF BACTERIAL
UROPATHOGENS CHANGE OVER THE YEARS IN
CHILDREN?
İkbal Nur Şafak 1
, Asli Kavaz Tufan 2
, Nuran Çetİn 2
, Ömer Kiliç 3
,
Gül Durmaz 4
1 Eskisehir Osmangazi University, Faculty Of Medicine, Department Of
Pediatrics
2 Eskisehir Osmangazi University, Faculty Of Medicine, Department Of
Pediatric Nephrology
3 Eskisehir Osmangazi University, Faculty Of Medicine,department Of
Pediatric Infectious Disease
4 Eskisehir Osmangazi University, Faculty Of Medicine, Department Of
Microbiology
Pediatr Nephrol (2021) 36:3285–3491 3487
Introduction: Urinary tract infections are among the most common infections of childhood and the development of resistance to antibiotics
causes treatment failure. Therefore, the aim of this study is to evaluate
the resistance patterns of uropathogens by years and to find risk factors
affecting the development of antibiotic resistance.
Material and methods: This study retrospectively assessed 1852 patients (1308 females) between 1 month and 18 years of age with a diagnosis of urinary tract infection and 2340 urine cultures of these patients
with uropathogen growth above 105 CFU/mL from January 2010 to
December 2019.
Results: The mean age was 73 ± 61 months (1-215 months) and the
number of urinary tract infection episodes was 2.5±3.8 (1-39). Urinary
tract anomalies were found in 15.7% of the patients, among which
hydronephrosis (8.8%) was the most common. The most common
uropathogens in urine culture were respectively E.coli (59.6%)
Klebsiella spp. (11.5%) and Enterococcus spp. (9.5%). There was a statistically significant increase in the growth rate of E.coli, Klebsiella
pneumoniae and Acinetobacter spp. by years (p <0.001). The frequency
of ESBL positive uropathogens was 16.2% at ten-year follow-up. ESBL
positivity was higher in infants, patients with recurrent UTIs, urinary
anomalies, and those who had used prophylactic antibiotics (p<0.05).
Antibiotics with the highest resistance were penicillin (60.8%), ampicillin
(55.7%) and trimethoprim-sulfamethoxazole (40.8%). While there was
no increase in resistance to carbapenems in ESBL positive E.coli, it was
found that imipenem and meropenem resistance increased in Klebsiella
strains (p <0.05).
Conclusions: In the treatment of UTI, especially in infants younger than 12
months, and those with urinary anomalies and a history of recurrent UTIs,
appropriate antibiotic should be chosen in accordance with local studies.