Carbazole and its derivatives are an important type of nitrogen containing aromatic heterocyclic compounds which have attracted considerable attention of medicinal chemists due to their antimicrobial activities. For this purpose, new carbazole derivatives were synthesized and evaluated for antimicrobial activity. As starting material 2-chloro-N-(9ethyl-9H-carbazol-3-yl) acetamide was prepared by the reaction of 3-amino-9-ethyl-9H-carbazole with chloroacetyl chloride. The reaction of 2-chloro-N-(9-ethyl-9H-carbazol-3-yl) acetamide with appropriate mercapto-heterocyclics resulted in the formation of the title compounds. The chemical structures of the compounds were elucidated by IR, 1H-NMR, FABMS spectral data and elemental analysis. Their antimicrobial activities against Candida albicans (two strains), Candida glabrata, Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa were investigated.