Use of rotational thromboelastography for a global screening of coagulation profile in patients of myeloproliferative neoplasms

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Gören Şahin D., Akay O. M., Üsküdar Teke H., Andıç N., Gündüz E.

Platelets, vol.32, no.2, pp.280-283, 2021 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 32 Issue: 2
  • Publication Date: 2021
  • Journal Name: Platelets
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.280-283
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Chronic myeloproliferative neoplasms (MPN) are clonal disorders of hematopoietic stem/progenitor

cell characterized by thrombohemorrhagic complications and a tendency to transform into

acute leukemia. The pathogenesis of thrombosis in MPN is complex and results from

a multifaceted interplay of clinical and disease-related factors. Rotational thromboelastometry

(ROTEM) provides the complete and rapid information about all stages of the coagulation process.

Here, we assess ROTEM parameters as a screening of coagulation profile in patients with MPNs. In

particular, higher mean maximum clot firmness values were found in Essential thrombocythemia

and Polycythemia vera patients when compared to healthy controls. Rotational thromboelastometry

may be able to detect MPN patients who are susceptible to thrombotic and/or hemorrhagic

complications. The predictive value of ROTEM for thrombosis remains to be established to classify

subsets of patients at prominent risk who may benefit from prophylaxis with antithrombotic drugs.