6. INTERNATIONAL HIPPOCRATES CONGRESS ON MEDİCAL AND HEALTH SCIENCES, Ankara, Türkiye, 30 Nisan - 01 Mayıs 2021, sa.1, ss.364-365
Coronavirus disease 2019 (COVID-19) is a novel and highly transmissable disease which has affected
millions of people worldwide. COVID-19 patients with multiple comorbidities including heart failure
(HF) show poor clinical outcomes. However, little is known about the effects of chronic kidney
disease(CKD) on clinical outcomes in HF patients with COVID-19. So, we aimed to evaluate the effect of
concomitant CKD on clinical outcomes in patients with HF who were hospitalized for COVID-19.
In this study, we retrospectively evaluated 240 consecutive patients hospitalized for COVID-19 who
had a previous diagnosis of HF with reduced or preserved ejection fraction in two centers, between March
15, 2020 and December 01, 2020. The diagnosis of HF was determined by searching for ICD-10: I50,
I50.1, I50.2, I50.9 in all available in-/outpatient hospital data. We compared clinical features, laboratory
findings and in-hospital outcomes according to estimated glomerular filtration rate (eGFR). Patients with
eGFR≥60 mL/min/1.73 m2 were determined as high eGFR group, and patients with eGFR<60
mL/min/1.73 m2 as low eGFR group. In-hospital clinical outcomes were defined as all-cause death,
respiratory failure requiring mechanical ventilation cardiogenic shock, length of intensive care unit (ICU)
stay and length of hospital stay.
Mean age of the study population was 73.2±10 years old and 67.5 % were male. One hundred and
fifty-two patients (63.3%) had an eGFR less than 60 mL/min/1.73 m2. There was no significant difference
between the two groups in terms of comorbidities include hypertension, diabetes, coronary artery disease
(p>0.05, for all). In the low eGFR group, the infection markers were significantly higher and the
haemoglobin value was also significantly lower (Table 1). Compared with patients with high eGFR, those
with low eGFR experienced longer length of intensive care unit (ICU) stay (4.0 days vs. 0.0 days;
p=0.003). Furthermore, clinical outcomes such as death, respiratory failure requiring mechanical
ventilation cardiogenic shock were worse in the low eGFR group.
This retrospective study of hospitalized patients with COVID-19 with HF showed that the presence of
low eGFR is associated with long ICU stay and worse clinical outcomes and laboratory parameters.