Atıf İçin Kopyala
DURAK A., OLĞAR Y., Degirmenci S., AKKUŞ E., TUNCAY E., Turan B.
CARDIOVASCULAR DIABETOLOGY, cilt.17, 2018 (SCI-Expanded)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
17
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Basım Tarihi:
2018
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Doi Numarası:
10.1186/s12933-018-0790-0
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Dergi Adı:
CARDIOVASCULAR DIABETOLOGY
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Derginin Tarandığı İndeksler:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
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Anahtar Kelimeler:
Diabetes, SGLT2 inhibitors, Heart function, Electrophysiology, Oxidative stress, Insulin resistance, OXIDATIVE STRESS, NA+/H+ EXCHANGER, DYSFUNCTION, HEART, EMPAGLIFLOZIN, OBESITY, CARDIOMYOCYTES, MORTALITY, ZN2+, PATHOPHYSIOLOGY
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Eskişehir Osmangazi Üniversitesi Adresli:
Hayır
Özet
Background: Metabolic syndrome (MetS) is a prevalent risk factor for cardiac dysfunction. Although SGLT2-inhibitors have important cardioprotective effects in hyperglycemia, their underlying mechanisms are complex and not completely understood. Therefore, we examined mechanisms of a SGLT2-inhibitor dapagliflozin (DAPA)-related cardioprotection in overweight insulin-resistant MetS-rats comparison with insulin (INSU), behind its glucose-lowering effect.