Is BECLIN-1 Immunoreactivity More Effective than HBME-1 in Diagnosis of Papillary Thyroid Cancer ?

Yesil C., Kandemir O., Haksever H., Dabakoglu T.

ACTA CHIRURGICA BELGICA, vol.115, no.4, pp.299-305, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 115 Issue: 4
  • Publication Date: 2015
  • Doi Number: 10.1080/00015458.2015.11681116
  • Journal Name: ACTA CHIRURGICA BELGICA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.299-305
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Background : Even though morphologic findings are generally important in the diagnosis of thyroid tumors, in some cases, morphologic similarities between benign and malignant lesions lead to noticeable differences in evaluation and different diagnoses in the same cases. In our study, we researched whether the autophagy-related protein Beclin-1 (BECN1) is a diagnostic marker in thyroid tumors, as well as its correlation with HBME-1, which has high sensitivity and specificity in distinguishing malignant thyroid lesions.