Molecular interactions of FDCs with B cells in aging

Szakal A., Aydar Y., Balogh P., Tew J.

SEMINARS IN IMMUNOLOGY, cilt.14, sa.4, ss.267-274, 2002 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 14 Sayı: 4
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1016/s1044-5323(02)00059-3
  • Dergi Adı: SEMINARS IN IMMUNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.267-274
  • Anahtar Kelimeler: FDC, B cell, aging, Fc gamma RII, CR1,2, FOLLICULAR DENDRITIC CELLS, GERMINAL CENTER DEVELOPMENT, IMMUNOLOGICAL MEMORY, LYMPHOID-TISSUE, ANTIGEN, RECEPTOR, PRECURSORS, FOLLICLES, RESPONSES, MICE
  • Eskişehir Osmangazi Üniversitesi Adresli: Hayır

Özet

Follicular dendritic cells (FDCs), as accessory cells to B cells, promote germinal center (GC) development. Age-related defects in the role of FDCs are well documented in vivo. In old mice, FDCs bind fewer immune complexes (ICs) and produce few iccosomes for endocytosis by B cells, antigen processing, and presentation to T cells. We recently studied whether these defects are due to changes in the FDC microenvironment or to changes in FDCs and their surface molecules. In vitro evidence suggests that age-related defects in both B cell stimulation via the BCR and co-stimulation via CD21/CD21L are related to IC-trapping by PDCs in vivo-a defect which is repairable, at least, in vitro.