Molecular interactions of FDCs with B cells in aging


Szakal A., Aydar Y., Balogh P., Tew J.

SEMINARS IN IMMUNOLOGY, vol.14, no.4, pp.267-274, 2002 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 14 Issue: 4
  • Publication Date: 2002
  • Doi Number: 10.1016/s1044-5323(02)00059-3
  • Journal Name: SEMINARS IN IMMUNOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.267-274
  • Keywords: FDC, B cell, aging, Fc gamma RII, CR1,2, FOLLICULAR DENDRITIC CELLS, GERMINAL CENTER DEVELOPMENT, IMMUNOLOGICAL MEMORY, LYMPHOID-TISSUE, ANTIGEN, RECEPTOR, PRECURSORS, FOLLICLES, RESPONSES, MICE
  • Eskisehir Osmangazi University Affiliated: No

Abstract

Follicular dendritic cells (FDCs), as accessory cells to B cells, promote germinal center (GC) development. Age-related defects in the role of FDCs are well documented in vivo. In old mice, FDCs bind fewer immune complexes (ICs) and produce few iccosomes for endocytosis by B cells, antigen processing, and presentation to T cells. We recently studied whether these defects are due to changes in the FDC microenvironment or to changes in FDCs and their surface molecules. In vitro evidence suggests that age-related defects in both B cell stimulation via the BCR and co-stimulation via CD21/CD21L are related to IC-trapping by PDCs in vivo-a defect which is repairable, at least, in vitro.