Which statin should be used together with colchicine? Clinical experience in three patients with nephrotic syndrome due to AA type amyloidosis


ŞAHİN G., KORKMAZ C., YALÇIN A. U.

RHEUMATOLOGY INTERNATIONAL, vol.28, no.3, pp.289-291, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 3
  • Publication Date: 2008
  • Doi Number: 10.1007/s00296-007-0435-1
  • Journal Name: RHEUMATOLOGY INTERNATIONAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.289-291
  • Keywords: amyloidosis, colchicine, familial mediterranean fever, neuromyopathy, statins, FAMILIAL MEDITERRANEAN FEVER, RHABDOMYOLYSIS, SIMVASTATIN, SECONDARY
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Colchicine and statins are well known drugs that cause myopathy and neuropathy. Co-administration of certain drugs with statins may increase myotoxic effect, causing myopathy and varying degrees of rhabdomyolysis. Therefore, it is very crucial to know which statin should be used during a combination therapy including colchicine and other drugs. We present three cases with AA amyloidosis secondary to familial Mediterranean fever, who developed neuromyopathy while receiving the combination of colchicine and statin. We also briefly discussed the different metabolic pathways of statins and colchicine when used together.