Synthesis of some triazolyl-antipyrine derivatives and investigation of analgesic activity

Turan-Zitouni G., Sivaci M., Kilic F. S., Erol K.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol.36, pp.685-689, 2001 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 36
  • Publication Date: 2001
  • Doi Number: 10.1016/s0223-5234(01)01252-1
  • Journal Name: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.685-689
  • Keywords: antipyrine, triazoles, analgesic activity
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

The synthesis of some triazolyl-antipyrine derivatives starting from 4-chloroacetamidoantipyrine and 3-(aryloxyalkyl)-4-ethyl/phenyl-5-mercapto-1,2,4-triazoles is described. The chemical structures of the compounds were elucidated by IR, H-1-NMR and mass spectral studies. These compounds were tested for analgesic activity. (C) 2001 Editions scientifiques et medicales Elsevier SAS.