First Synthesis of Multi‐Stimuli Responsive PMOEP Microgels: Phosphorus‐Based Platform for Controlled Drug Delivery

Samav Y., Tuncer C.

CHEMPLUSCHEM, cilt.91, sa.9, ss.1-16, 2026 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 91 Sayı: 9
  • Basım Tarihi: 2026
  • Doi Numarası: 10.1002/cplu.70232
  • Dergi Adı: CHEMPLUSCHEM
  • Derginin Tarandığı İndeksler: Applied Science & Technology Source, Academic Search Ultimate (EBSCO), Natural Science Collection (ProQuest), Earth, Atmospheric, & Aquatic Science Collection (ProQuest), Scopus, Materials Science & Engineering Collection (ProQuest), Pharma Collection (ProQuest), Technology Collection (ProQuest), Science Citation Index Expanded (SCI-EXPANDED), Chemical Abstracts Core, Chimica, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.1-16
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

In this study, novel phosphorus‐containing and pH‐responsive poly[2‐(methacryloyloxy)ethyl phosphate] (PMOEP) microgels

were successfully synthesized for the first time via emulsion polymerization using a PBzDMA‐b‐PMEMA diblock copolymer

steric stabilizer. Their performance was systematically compared with poly[2‐(diethylamino)ethyl methacrylate] (PDEA) microgels

cross‐linked with multifunctional phosphorus agents (DMEP, TMEP) and EGDMA. Dynamic light scattering (DLS) analysis

demonstrated that while EGDMA‐cross‐linked PDEA microgels exhibited a volumetric swelling capacity of 3330%, PMOEP

microgels reached a significantly lower swelling ratio of 594% under identical conditions. Electrokinetic and DLS measurements

revealed high colloidal stability across pH 3–12. The electrophoretic mobility (μ

e

) remained consistently negative, shifting from

−1.20 × 10

−8

 m

2 

V

−1 

s

−1

 at pH 3.3 to a maximum magnitude of −2.49 × 10

−8

 m

2 

V

−1 

s

−1

 at pH 11.2, providing a robust evaluation

of surface charge without model‐dependent conversions for swollen soft structures. Furthermore, PMOEP microgels displayed

multi‐stimuli responsiveness to pH, temperature, and salt concentration. Evaluated using Ibuprofen as a model drug under

physiological conditions (pH 7.4, 37 °C), in vitro release showed a biphasic sustained profile, reaching 100% cumulative release over

113 h. These findings demonstrate that potentially biocompatible, phosphonic acid‐functionalized microgels represent a versatile

platform for advanced controlled drug delivery systems.