Synthesis of some 2-[(benzazole-2-yl)thioacetylamino]thiazole derivatives and their antimicrobial activity and toxicity

Turan-Zitouni, G; Demirayak, E; Ozdemir, A; Kaplancikli, ZA; Yildiz, MT

doi:10.1016/j.ejmech.2003.11.001

Synthesis of some 2-[(benzazole-2-yl)thioacetylamino]thiazole derivatives and their antimicrobial activity and toxicity

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Turan-Zitouni G., Demirayak E., Ozdemir A., Kaplancikli Z., Yildiz M.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol.39, no.3, pp.267-272, 2004 (SCI-Expanded)

Publication Type: Article / Article
Volume: 39 Issue: 3
Publication Date: 2004
Doi Number: 10.1016/j.ejmech.2003.11.001
Journal Name: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.267-272
Eskisehir Osmangazi University Affiliated: No

Abstract

Some 2-[(benzazole-2-yl)thioacetylamino]thiazole derivatives (III) were synthesized by reacting 4-methyl-2-(chloroacetylamino)thiazole derivatives (I) with benzazol-2-thiole (II) in acetone in the presence of K2CO3. The chemical structures of the compounds were elucidated by H-1 NMR and FAB(+)-MS spectral data. The prepared compounds were tested for antimicrobial activity and toxicity. (C) 2003 Elsevier SAS. All rights reserved.