The Effects of Beta Amyloid Peptide 1-42 on Isolated Rat Hearts and Ileum Smooth Muscle

Yousefirad N., Kaygisiz Z., AYDIN Y.

PHARMACOLOGY, cilt.98, ss.261-266, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 98
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1159/000448590
  • Dergi Adı: PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.261-266
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Neurotoxic beta amyloid peptides (beta APs) are involved in the pathogenesis of Alzheimer disease. beta AP(1-42) may also play a role in the regulation of cardiovascular functions. Therefore, we investigated the possible effects of beta AP(1-42) on isolated rat heart and ileum. The hearts were perfused with modified Krebs-Henseleit solution. Left ventricular developed pressure (LVDP), maximal rate of pressure development of left ventricle (+dP/dt(max)), heart rate, coronary flow, monophasic action potential amplitude (MAPamp), MAP duration at 90% repolarization (MAP(90)) and contractions of ileum were measured. One, 10 and 100 nmol/l doses of beta AP(1-42) significantly decreased LVDP, +dP/dt(max) and heart rate. The dose of 1 nmol/l did not change coronary flow, but 10 and 100 nmol/l doses significantly reduced it. All doses of beta AP(1-42) did not alter MAPamp, but increased MAP(90). beta AP(1-42) (1, 10, 100, 1,000 nmol/l) also did not influence ileum contractions. We suggest that beta AP(1-42) produces negative inotropic and negative chronotropic effects with an increase in MAP duration. Furthermore, beta AP(1-42) at high doses decreases coronary flow. (C) 2016 S. Karger AG, Basel