Hyaluronic acid hydrogel particles with tunable charges as potential drug delivery devices

EKİCİ S., ILGIN P., Butun S., ŞAHİNER N.

CARBOHYDRATE POLYMERS, cilt.84, sa.4, ss.1306-1313, 2011 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 84 Sayı: 4
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1016/j.carbpol.2011.01.028
  • Dergi Adı: CARBOHYDRATE POLYMERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1306-1313
  • Anahtar Kelimeler: Hyaluronic acid hydrogel particles, Natural and synthetic composites, Polyelectrolytes, Drug release, Biocompatible, CONTROLLED-RELEASE, NANOPARTICLES, DEGRADATION, DERIVATIVES, MICELLES, DESIGN
  • Eskişehir Osmangazi Üniversitesi Adresli: Hayır

Özet

We report the synthesis of hyaluronic acid (HA) particles with positive and negative charges on their surfaces. HA-based particles were prepared using an aqueous solution of linear HA in a sodium bis(2-ethylhexyl) sulfosuccinate (AOT)-isooctane microemulsion system. The prepared HA particles were post modified, i.e., oxidized to aldehyde (HA-O) by NaIO4 treatment and then these HA-O particles were reacted with cysteamine (CYs) to obtain thiol groups on the surface of the HA particles. The thiolated HA particles (HA-CYs) were further exposed to radical polymerization with an anionic monomer, 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS), and with a cationic monomer, 3-acrylamidopropyl-trimethylammonium chloride (APTMACl), to generate HA-based ionic hydrogel particles, HA-CYs-AMPS and HA-CYs-APTMACl, respectively. The prepared HA-based anionic and cationic particles illustrated strong pH dependent size variations. We demonstrated that HA-CYs-AMPS and HA-CYs-APTMACl particles can be used as drug delivery vehicles. Trimethoprim (TMP) and naproxen (NN) were used as model drugs in the drug delivery experiments. (C) 2011 Elsevier Ltd. All rights reserved.