Does trimetazidine pretreatment affect cardiopulmonary bypass-induced inflammation during coronary artery grafting?
PERFUSION, cilt.16, sa.9, ss.318-323, 2003 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 16 Sayı: 9
- Basım Tarihi: 2003
- Dergi Adı: PERFUSION
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.318-323
- Eskişehir Osmangazi Üniversitesi Adresli: Evet
Özet
Background: Cardiac surgery involving cardiopulmonary bypass is associated with reperfusion injury and an inflammatory process. In a previous study, we showed the potential myocardial protective effects of trimetazidine pretreatment by measuring the cardiac marker protein troponin T (TnT) during coronary bypass operations. However, it is not known whether trimetazidine has a preventive effect on the cardiopulmonary bypass-induced inflammation. The aim of the present study was to investigate whether pretreatment with trimetazidine, a cellular anti-ischemic agent can prevent the deleterious effects of cardiopulmonary bypass-induced inflammation.