Akademik Veri Yönetim Sistemi
ACTA MEDICA MEDITERRANEA, cilt.33, sa.4, ss.549-555, 2017 (SCI-Expanded)
Background: The role of molecular markers in ovarian cancer is still a matter of debate. This study was conducted to determine the clinical significance of serum Omentin-1 in epithelial ovarian cancer (EOC) patients in the current matched case-control study. Material and methods: Fourty-one patients with advanced EOC and 41 healthy people were included in the study. Serum Omentin values were measured by quantitative ELISA method. Results: The median serum Omentin-1 values was 46.6 pg/ml in patients and this was significantly higher than healthy controls (median 35.5) (p=0.045). There was positive correlation between serum omentin and serum CA-125 levels (r = 0.34, p =0.028). We found no relationship between serum Omentin-1 levels and any prognostic parameters analyzed, including age of the patients, histology, tumor grade, stage of the disease, debulking surgery and response to chemotherapy. Survival analysis did not show statistically significant effect of serum Omentin-1 level on overall survival (p = 0.91) Conclusions: These results indicated that serum Omentin-1 values were significantly elevated in patients with advanced overian carcinoma compared to healthy people. Further studies with a greater number of patients are required to confirm the importance of serum Omentin-1 levels in ovarian cancer.