Determination of parabens in pharmaceutical and cosmetic products by capillary electrophoresis

Uysal U. D., Gueray T.

JOURNAL OF ANALYTICAL CHEMISTRY, cilt.63, sa.10, ss.982-986, 2008 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 63 Sayı: 10
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1134/s1061934808100109
  • Dergi Adı: JOURNAL OF ANALYTICAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.982-986
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

A validated capillary electrophoresis method for the determination of parabens-methyl, ethyl, propyl, and butyl is described. The optimum results were obtained by the use of a run buffer containing 20 mM borate buffer (pH 9.0) with 10% methanol and by applying a voltage of 20 kV, a low hydrodynamic injection of 10 s, and detecting the signals at 200 nm. Moxifloxazin was used as an internal standard. All parabens were separated within 10 min. The method showed a good repeatability, linearity, and sensitivity. It was applied to the determination of parabens in pharmaceutical and certain cosmetic products.