Effect of etanercept and lithium chloride on preventing secondary tissue damage in rats with experimental diffuse severe brain injury

Ekici M. A., UYSAL O., Cikriklar H. I., Ozbek Z., TURGUT COŞAN D., Baydemir C., ...Daha Fazla

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, cilt.18, sa.1, ss.10-27, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 1
  • Basım Tarihi: 2014
  • Dergi Adı: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.10-27
  • Anahtar Kelimeler: Traumatic brain injury, Etanercept, Lithium chloride, TNF-alpha, NECROSIS-FACTOR-ALPHA, SPINAL-CORD-INJURY, FIBRILLARY ACIDIC PROTEIN, FOCAL CEREBRAL-ISCHEMIA, TAU-PROTEIN, RHEUMATOID-ARTHRITIS, NEURONAL DAMAGE, TNF-ALPHA, EXPRESSION, MODEL
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

OBJECTIVE: Studies in animals have provided key evidence that antagonizing TNF-alpha is a viable therapeutic strategy for diffuse severe brain injury. This study is planned to prevent post-traumatic secondary tissue damages in rat diffuse severe brain injury model, which is induced by alone or combined administration of Etanercept and lithium chloride (LiCl).