Effect of etanercept and lithium chloride on preventing secondary tissue damage in rats with experimental diffuse severe brain injury

Ekici, M.; UYSAL, ONUR; Cikriklar, H.; Ozbek, Z.; TURGUT COŞAN, DİDEM; Baydemir, C.; Kazanci, B.; Hafizoglu, D.

Effect of etanercept and lithium chloride on preventing secondary tissue damage in rats with experimental diffuse severe brain injury

Ekici M. A., UYSAL O., Cikriklar H. I., Ozbek Z., TURGUT COŞAN D., Baydemir C., ...More

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, vol.18, no.1, pp.10-27, 2014 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 18 Issue: 1
Publication Date: 2014
Journal Name: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.10-27
Keywords: Traumatic brain injury, Etanercept, Lithium chloride, TNF-alpha, NECROSIS-FACTOR-ALPHA, SPINAL-CORD-INJURY, FIBRILLARY ACIDIC PROTEIN, FOCAL CEREBRAL-ISCHEMIA, TAU-PROTEIN, RHEUMATOID-ARTHRITIS, NEURONAL DAMAGE, TNF-ALPHA, EXPRESSION, MODEL
Eskisehir Osmangazi University Affiliated: Yes

Abstract

OBJECTIVE: Studies in animals have provided key evidence that antagonizing TNF-alpha is a viable therapeutic strategy for diffuse severe brain injury. This study is planned to prevent post-traumatic secondary tissue damages in rat diffuse severe brain injury model, which is induced by alone or combined administration of Etanercept and lithium chloride (LiCl).