PTU-induced ANCA-positive vasculitis: an innocent or a life-threatening adverse effect?

Bilge N. Ş., KAŞİFOĞLU T., KORKMAZ C.

RHEUMATOLOGY INTERNATIONAL, cilt.33, sa.1, ss.117-120, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 1
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1007/s00296-011-2280-5
  • Dergi Adı: RHEUMATOLOGY INTERNATIONAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.117-120
  • Anahtar Kelimeler: Propylthiouracil, ANCA, Vasculitis, Hyperthyroidism, ANTINEUTROPHIL CYTOPLASMIC ANTIBODY, PATHOGENESIS
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitides are rare, but they can be triggered by chemicals, infections and drugs; among them, antithyroid drugs are common. Autoimmune disorders, such as vasculitis, are unusual, but serious complications of antithyroid therapy. Both propylthiouracil (PTU) and methimazole may induce ANCA-associated vasculitis. PTU-induced vasculitides may have different organ involvement patterns. Herein, we report four cases with ANCA-associated vasculitis with different clinical manifestations.