PTU-induced ANCA-positive vasculitis: an innocent or a life-threatening adverse effect?

Bilge N. S. Y., KAŞİFOĞLU T., KORKMAZ C.

RHEUMATOLOGY INTERNATIONAL, vol.33, no.1, pp.117-120, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 1
  • Publication Date: 2013
  • Doi Number: 10.1007/s00296-011-2280-5
  • Journal Name: RHEUMATOLOGY INTERNATIONAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.117-120
  • Keywords: Propylthiouracil, ANCA, Vasculitis, Hyperthyroidism, ANTINEUTROPHIL CYTOPLASMIC ANTIBODY, PATHOGENESIS
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitides are rare, but they can be triggered by chemicals, infections and drugs; among them, antithyroid drugs are common. Autoimmune disorders, such as vasculitis, are unusual, but serious complications of antithyroid therapy. Both propylthiouracil (PTU) and methimazole may induce ANCA-associated vasculitis. PTU-induced vasculitides may have different organ involvement patterns. Herein, we report four cases with ANCA-associated vasculitis with different clinical manifestations.