Intrahepatic cholestasis is a rare manifestation of paraneoplastic syndrome and has been reported to be associated with various malignancies. Intrahepatic cholestasis without a mechanical obstruction has been previously reported in only three prostate carcinoma cases in English literature. In this report, we described a new case of paraneoplastic intrahepatic cholestasis in a patient with prostate carcinoma treated only with bilateral orchiectomy. We also discussed the mechanisms of cholestasis in prostate carcinoma in the light of the pertinent literature. Paraneoplastic cholestasis should be kept in mind in the absence of biliary tract obstruction and hepatic involvement in prostate carcinoma. Patients with unexplained cholestasis should be investigated for a possible paraneoplastic syndrome. Paraneoplastic cholestasis resolves following orchiectomy in prostate carcinoma cases.