Paraneoplastic Cholestasis in Prostate Carcinoma: A Case Report and Review of the Literature

Ertugrul I., Basar O., Odemis B., YÜKSEL İ., DİŞİBEYAZ S., Turhan N., ...Daha Fazla

TURKIYE KLINIKLERI TIP BILIMLERI DERGISI, cilt.30, sa.5, ss.1756-1759, 2010 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 30 Sayı: 5
  • Basım Tarihi: 2010
  • Doi Numarası: 10.5336/medsci.2008-10266
  • Dergi Adı: TURKIYE KLINIKLERI TIP BILIMLERI DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1756-1759
  • Eskişehir Osmangazi Üniversitesi Adresli: Hayır

Özet

Intrahepatic cholestasis is a rare manifestation of paraneoplastic syndrome and has been reported to be associated with various malignancies. Intrahepatic cholestasis without a mechanical obstruction has been previously reported in only three prostate carcinoma cases in English literature. In this report, we described a new case of paraneoplastic intrahepatic cholestasis in a patient with prostate carcinoma treated only with bilateral orchiectomy. We also discussed the mechanisms of cholestasis in prostate carcinoma in the light of the pertinent literature. Paraneoplastic cholestasis should be kept in mind in the absence of biliary tract obstruction and hepatic involvement in prostate carcinoma. Patients with unexplained cholestasis should be investigated for a possible paraneoplastic syndrome. Paraneoplastic cholestasis resolves following orchiectomy in prostate carcinoma cases.