Tumor necrosis factor-alpha gene polymorphisms in children with multiple sclerosis

Anlar B., Alikasifoglu M., Kose G., Guven A., Gurer Y., Yakut A.

NEUROPEDIATRICS, cilt.32, sa.4, ss.214-216, 2001 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 4
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1055/s-2001-17376
  • Dergi Adı: NEUROPEDIATRICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.214-216
  • Eskişehir Osmangazi Üniversitesi Adresli: Hayır

Özet

Tumor necrosis factor-alpha (TNF-alpha) is a cytokine implicated in the pathogenesis of infectious and autoimmune disorders including multiple sclerosis (MS). Childhood-onset MS presents some clinical and laboratory features differing from adult disease. We studied TNF-alpha - 238 G -->A and - 308 G -->A polymorphisms in 24 patients with childhood-onset MS using PCR-RFLP and compared them with healthy control subjects from the same population (n = 93). The genotypes and allele frequencies were not different between patient and control groups (p=0.348, 95%Cl, 0.28-1.92, chi (2)=0.10 and p=0.797, 95%Cl, 0.312 - 2.285, chi (2) = 0.20 for - 238 and - 308 alleles, respectively). Although the size of the study group is small, these results do not support a role for TNF-alpha gene polymorphisms in susceptibility to MS in children.