Tumor necrosis factor-alpha gene polymorphisms in children with multiple sclerosis

Anlar B., Alikasifoglu M., Kose G., Guven A., Gurer Y., Yakut A.

NEUROPEDIATRICS, vol.32, no.4, pp.214-216, 2001 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 4
  • Publication Date: 2001
  • Doi Number: 10.1055/s-2001-17376
  • Journal Name: NEUROPEDIATRICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.214-216
  • Eskisehir Osmangazi University Affiliated: No

Abstract

Tumor necrosis factor-alpha (TNF-alpha) is a cytokine implicated in the pathogenesis of infectious and autoimmune disorders including multiple sclerosis (MS). Childhood-onset MS presents some clinical and laboratory features differing from adult disease. We studied TNF-alpha - 238 G -->A and - 308 G -->A polymorphisms in 24 patients with childhood-onset MS using PCR-RFLP and compared them with healthy control subjects from the same population (n = 93). The genotypes and allele frequencies were not different between patient and control groups (p=0.348, 95%Cl, 0.28-1.92, chi (2)=0.10 and p=0.797, 95%Cl, 0.312 - 2.285, chi (2) = 0.20 for - 238 and - 308 alleles, respectively). Although the size of the study group is small, these results do not support a role for TNF-alpha gene polymorphisms in susceptibility to MS in children.