Is there any genetic predisposition of MMP-9 gene C1562T and MTHFR gene C677T polymorphisms with essential hypertension?

Bayramoglu A., URHAN KÜÇÜK M., GÜLER H. İ., Abaci O., Kucukkaya Y., ÇOLAK E.

CYTOTECHNOLOGY, cilt.67, sa.1, ss.115-122, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 67 Sayı: 1
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1007/s10616-013-9665-0
  • Dergi Adı: CYTOTECHNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.115-122
  • Anahtar Kelimeler: Essential hypertension, MMP-9, MMP-9 C1562T polymorphism, MTHFR, MTHFR C677T polymorphism, METHYLENETETRAHYDROFOLATE REDUCTASE GENE, MATRIX METALLOPROTEINASES, ENZYME-ACTIVITY, BLOOD-PRESSURE, RISK-FACTOR, ASSOCIATION, GELATINASES, FREQUENCY, GENOTYPES, VARIANT
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

The current study was conducted to determine whether there is a relation between hypertension and two different polymorphisms, including C1562T of the Matrix metalloproteinase-9 (MMP-9) gene and C677T of the methylenetetrahydrofolate reductase (MTHFR) gene. Genomic DNA obtained from 224 persons (125 patients with hypertension and 99 healthy controls) were used in the study. Polymorphisms were determined by using polymerase chain reaction-restriction fragment length polymorphism and electrophoresis. The results were statistically analyzed and were found to be statistically significant. The frequencies of the C1562T genotypes were found to be, in controls CC 75.8 % and CT 24.2 % and in patients CC 71.2 %, and CT 28.8 %. The frequencies of C677T genotype were found to be, in controls CC 56.6 %, CT 38.4 and TT 5.1 % in controls and in patients CC 52 %, CT 30.4 % and TT 17.6 %. In conclusion, we may suggest that there is no relation between the essential hypertension and C1562T polymorphism of MMP-9 gene; on the other hand C677T polymorphism (genotype TT) of MTHFR gene can be regarded as a genetic indicator for the development of essential hypertension.