Effect of ovulation induction on liver histopathology and functions in an experimental model of ovarian hyperstimulation syndrome

Alatas E., Alatas O., Kasapoglu E.

MEDICAL SCIENCE RESEARCH, vol.24, no.9, pp.629-630, 1996 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 9
  • Publication Date: 1996
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.629-630
  • Eskisehir Osmangazi University Affiliated: Yes


In the rabbit model of the ovarian hyperstimulation syndrome, animals given hMG-hCG demonstrated increases in mean plasma serum glutamic oxaloacetic transaminase (SGOT) activity and plasma progesterone, and transient increases in serum glutamic pyruvic transaminase (SGPT) and gamma glutamyl transpeptidase (GGT) activities. No significant difference was observed in plasma estradiol (E2) concentrations. Light microscopic examination of liver biopsies showed a normal lobular pattern except for congestion. We conclude that liver function test alterations due to high steroid levels or enhanced vascular permeability may be a part of the abnormalities related to ovarian hyperstimulation syndrome.