Synthesis and antimicrobial activity of some pyrazoline derivatives bearing amide moiety

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ÖZDEMİR A.

MARMARA PHARMACEUTICAL JOURNAL, vol.17, no.3, pp.187-192, 2013 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 3
  • Publication Date: 2013
  • Doi Number: 10.12991/2013171314
  • Journal Name: MARMARA PHARMACEUTICAL JOURNAL
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.187-192
  • Eskisehir Osmangazi University Affiliated: No

Abstract

In the present study, a series of pyrazoline derivatives were synthesized. The chemical structures of the compounds were elucidated by IR, H-1-NMR, C-13-NMR and FAB+-MS spectral data and elemental analyses. The synthesized compounds were screened for their antimicrobial activities. All compounds exhibited the highest antibacterial activity against P. aeruginosa. All compounds except compounds 1-(chloroacetyl)-3-(2-furanyl)-5-(4chlorophenyl)-2-pyrazoline and 1-(chloroacetyl)-3-(2-thienyl)-5-(3,4-methylenedioxyphenyl)2-pyrazoline are more effective than ketoconazole against C. albicans, whereas compounds 1-(chloroacetyl)-3-(2-furanyl)-5-(4-chlorophenyl)-2-pyrazoline, 1-(chloroacetyl)-3-(2-thienyl)-5-( 3,4-methylenedioxyphenyl)-2-pyrazoline and ketoconazole showed the same level of antifungal activity against C. albicans.