Relationship between NT-proBNP levels and existing/de novo QRS fragmentation in patients with myocardial infarction

Sunman H., Algül E., DURAL M., Erzurum M., Aydınyılmaz F., Efe T. H., ...More

Biomarkers in Medicine, vol.18, no.10-12, pp.535-544, 2024 (SCI-Expanded, Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 10-12
  • Publication Date: 2024
  • Doi Number: 10.1080/17520363.2024.2345584
  • Journal Name: Biomarkers in Medicine
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, EMBASE, MEDLINE
  • Page Numbers: pp.535-544
  • Keywords: acute myocardial infarction, fragmented QRS, N-terminal pro-brain natriuretic peptide
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Aim: to assess the evolution of fragmented QRS (fQRS) and NT-proBNP levels during myocardial infarction (MI). Methods: Among 511 patients, 205 (40.1%) had fQRS, with 54 (26.3%) developing de novo fragmentation during hospitalization. Results: NT-proBNP levels were significantly higher in the fQRS+ group compared with the fQRS- group (1555 vs. 796 pg/ml, p < 0.001). NT-proBNP levels were higher in patients with de novo fragmentation than in those without (2852 vs. 1370 pg/ml, p = 0.011). The incidence of major adverse cardiovascular events was notably higher in fQRS+ patients compared with fQRS- patients (p = 0.001). Conclusion: In acute MI, there was a significant association between fQRS and NT-proBNP levels, with higher NT-proBNP levels observed in those with de novo fQRS compared with those without.