Geomorphological and sedimentological investigations coupled with cosmogenic datings from a Plio-Pleistocene fluvial succession and fluvial landscape atop along the southern Eskisehir Fault Zone allowed understanding the morphotectonic history and the rate of vertical displacement in Eskisehir region. Our observations showed that the north-flowing aggradational rivers at 920 In altitude became degradational ca. 150 ka ago clue to tectonically induced base-level drop in the nearby fault zone. While the two parallel-running meandering valleys were still developing at 850 m altitudes, one of the branches of eastern river captured the western river. This event caused the western valley abandoned and the terrace formations in the eastern valley. Near to and within the fault zone, both the abandoned valley floor and the fluvial terrace that dated back to 35-39 ka by C-14 and Cl-35 cosmogenic methods has been vertically displaced about 40 m since their formation. The calculated uplift rate of ca. 1 mm/a for the southern Eskisehir Fault Zone and its presumed onset age were compared with existing data froth various sources. It is concluded that this intermediate uplift rate better conforms with the significant seismicity prevailing in the Zone. It is also suggested that the relatively Younger age (ca. 150 ka) of the southern Eskisehir Fault Zone may be genetically related with the increased extension rates due to full development of North Anatolian Fault Zone in the Sea of Marmara at about 200 ka.