Synthesis of some 4-arylidenamino-4H-1,2,4-triazole-3-thiols and their antituberculosis activity

Ozdemir A., Turan-Zitouni G., Kaplancikli Z. A., Chevallet P.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol.22, no.4, pp.511-516, 2007 (SCI-Expanded) identifier identifier identifier


The increasing clinical importance of drug-resistant mycobacterial pathogens has lent additional urgency to microbiological research and new antimycobacterial compound development. For this purpose, new triazoles were synthesized and evaluated for antituberculosis activity. A series of 4-arylidenamino-4H-1,2,4-triazole-3-thiol derivatives ( 2a-n) were synthesized from the treatment of 4-amino-4H-1,2,4-triazoles-3-thiol ( 1) with the respective aldehydes and were evaluated for antituberculosis activity against Mycobacterium tuberculosis H(37)Rv ( ATCC 27294), using the BACTEC 460 radiometric system and BACTEC 12B medium. Compound 2k showed an intereting activity at 6.25 mu g/mL with a 87 percentage inhibition.