Microorganisms isolated from cultures and infection focus and antibiotic treatments in febrile neutropenic children from Sanliurfa, Turkey


ÖZDEMİR Z. C. , KOÇ A., AYÇİÇEK A.

TURKISH JOURNAL OF PEDIATRICS, vol.58, no.1, pp.47-53, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 58 Issue: 1
  • Publication Date: 2016
  • Doi Number: 10.24953/turkjped.2016.01.007
  • Title of Journal : TURKISH JOURNAL OF PEDIATRICS
  • Page Numbers: pp.47-53

Abstract

Chemotherapy induced febrile neutropenia predisposes patients to life threatening infections. We aimed to determine the causative microorganisms, infection focus and antibiotic treatment success in febrile neutropenic children with leukemia. A total of 136 febrile neutropenic episodes in 48 leukemic children were reviewed retrospectively from records. Among 136 febrile neutropenic episodes, 68 (50%) episodes were microbiologically documented. Methicillin sensitive coagulase (-) Staphylococcus aureus were the most common isolates from hemoculture (20.5%). The most frequently documented infection focus was mucositis (31.9%). Ceftazidime plus amikacin was the most commonly used antimicrobial treatment for the empirical therapy (52.9%). The overall response rates were 70.5%, 86.9%, and 66.6% of first line, second line and third line therapies, respectively.