Toxic Epidermal Necrolysis (TEN) is a rare and life threatening mucocutaneous disease. It is characterized by the separation of significant areas of skin at the dermal-epidermal junction due to extensive keratinocyte cell death and the appearance of scalded skin. It is frequently related to drug intake. Toxic Epidermal Necrolysis following administration of nonionic iodinated contrast media is very rare. In this paper, we report a case of TEN induced by nonionic iodinated contrast medium iohexol.