Clonidine pretreatment inhibits stress-induced gastric ulcer in rats


Yelken B., Dorman T., Erkasap S., Dundar E., Tanriverdi B.

ANESTHESIA AND ANALGESIA, cilt.89, sa.1, ss.159-162, 1999 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 89 Sayı: 1
  • Basım Tarihi: 1999
  • Doi Numarası: 10.1097/00000539-199907000-00028
  • Dergi Adı: ANESTHESIA AND ANALGESIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.159-162
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

We studied the effects of clonidine (0.5 mg/kg) on hormonal stress response and antioxidant enzymes cold restraint-induced gastric lesions in rats. Rats in the study group were given 0.5 mg/kg intraperitoneal clonidine (n = 12), whereas the control group received 0.5 mL/kg intraperitoneal isotonic sodium chloride solution (n = 9). Animals were then subjected to immobilization at 4 degrees C in restraining devices for 4 h after a starvation period of 24 h. Gastric lesion index, gastric tissue malondialdehyde activity, and plasma cortisol concentrations were assayed. Histopathologic examination demonstrated a stress ulcer index of 3.17 +/- 0.92 mm in the clonidine group and 14.0 +/- 3.22 mm in the control group (P < 0.05). The tissue malondialdehyde concentrations were slightly higher in the control group than in the clonidine group, but the differences were not statistically significant (P > 0.05). Plasma cortisol levels were lower in the clonidine group (P < 0.05). We concluded that clonidine attenuated the tissue damage and stress response in stress-induced gastric ulceration. Implications: Stressful circumstances can cause stomach ulcers, which can bleed, exposing patients to potentially life-threatening complications. In the present animal study we showed that clonidine, a routinely available medication, may be useful in preventing stress-induced stomach ulcers.