Rotational thromboelastometry profile in children with chronic spontaneous urticaria

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Anıl H., Harmancı K., Özdemir Z. C., Bör Ö., Gündüz E., Koçak A., ...More

Journal Of Pediatric Hematology Oncology, vol.43, no.2, pp.159-161, 2021 (SCI-Expanded)

  • Publication Type: Article / Article
  • Volume: 43 Issue: 2
  • Publication Date: 2021
  • Journal Name: Journal Of Pediatric Hematology Oncology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE
  • Page Numbers: pp.159-161
  • Eskisehir Osmangazi University Affiliated: Yes


The pathogenesis of chronic spontaneous urticaria (CSU)

is incompletely understood. There is a growing interest in the role of

the coagulation cascade in chronic urticaria. Rotational thromboelastometry

(ROTEM) assay enables the global assessment of coagulation

status. In the present study, we aimed to test the coagulation

profile in children with CSU using ROTEM and correlate these

parameters with those of a healthy group. A total of 24 children with

active CSU (11 girls and 13 boys) 8 to 17 years of age and agematched

and sex-matched 30 healthy control participants were

enrolled in the study. ROTEM assays (intrinsic thromboelastometry

and extrinsic thromboelastometry) were used to measure and analyze

coagulation time, clot formation time, and maximum clot firmness.

The CSU patients and controls did not differ in age, sex, erythrocyte,

neutrophil, and platelet counts. Also, ROTEM parameters did not

show any difference between the 2 groups. ROTEM is increasingly

being used as a tool for monitoring coagulation status. In this study,

ROTEM parameters did not show any difference between CSU

patients and the healthy group. Further studies are needed to confirm

our findings on a larger number of CSU patients.