Research Information System
Journal Of Pediatric Hematology Oncology, vol.43, no.2, pp.159-161, 2021 (SCI-Expanded)
The pathogenesis of chronic spontaneous urticaria (CSU)
is incompletely understood. There is a growing interest in the role of
the coagulation cascade in chronic urticaria. Rotational thromboelastometry
(ROTEM) assay enables the global assessment of coagulation
status. In the present study, we aimed to test the coagulation
profile in children with CSU using ROTEM and correlate these
parameters with those of a healthy group. A total of 24 children with
active CSU (11 girls and 13 boys) 8 to 17 years of age and agematched
and sex-matched 30 healthy control participants were
enrolled in the study. ROTEM assays (intrinsic thromboelastometry
and extrinsic thromboelastometry) were used to measure and analyze
coagulation time, clot formation time, and maximum clot firmness.
The CSU patients and controls did not differ in age, sex, erythrocyte,
neutrophil, and platelet counts. Also, ROTEM parameters did not
show any difference between the 2 groups. ROTEM is increasingly
being used as a tool for monitoring coagulation status. In this study,
ROTEM parameters did not show any difference between CSU
patients and the healthy group. Further studies are needed to confirm
our findings on a larger number of CSU patients.