The aim of the study was to determine relationships between depression, quality of life and other possible factors among postmenopausal women in western Turkey. This cross-sectional study was realized from 01 January to 28 February 2018. The study group was formed with 802 postmenopausal women. Beck's Depression Inventory (BDI) was used to assess the level of depression. The severity of menopause-related symptoms was assessed using the Menopause Rating Scale (MRS). Health-Related Quality of Life Scale Short Form (SF-36) was used to evaluate the quality of life. Logistic Regression Analysis (Backward Wald) was used to determine the risk factors for depression. Statistical significance was accepted as p <= 0.05. The prevalence of depression was 22.7%. According to the logistic model, being divorce (OR: 1.847), low family income (OR: 1.929), chronic disease history (OR: 1.653), obesity (OR: 1.484), history of domestic violence (OR: 2.168) and sleep problems (OR: 2.76) were found to be important risk factors for depression in postmenopausal women (for each one, p <= 0.05). For all sub-domains of SF-36, the scores were lower in women with depression compared to others (p <= 0.05 for each one). There was a weak positive relationship between total scores obtained from MRS and BDI scores (r = 0.406; p = 0.001). It may be useful to conduct awareness-raising studies on depression for postmenopausal women and to screen for suspicious cases and to refer them to advanced health centres.