Synthesis and effects on intracellular calcium of some 1,3-bis-(heteroaryl substituted)benzene derivatives

Meric A., Incesu Z., Isikdag I.

FARMACO, vol.57, no.7, pp.543-548, 2002 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 57 Issue: 7
  • Publication Date: 2002
  • Doi Number: 10.1016/s0014-827x(02)01246-6
  • Journal Name: FARMACO
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.543-548
  • Eskisehir Osmangazi University Affiliated: No


A series of 1,3-bis-(heteroaryl substituted)benzene derivatives was designed as promising molecules which might increase intracellular Ca2+ level in F2408 fibroblast-like cells by affecting the Ca2+ channels on plasma membrane. Mentioned compounds were obtained by the treatment of isophtalaldehyde with benzil or 1,2-phenylenediamine derivatives. In this way, 13 compounds were synthesised and their structure elucidations were performed by IR, H-1 NMR and mass spectroscopic data and elemental analysis results. Some of the compounds showed Ca2+ being released from the intact cells. (C) 2002 editions scientifiques et medicales Elsevier SAS. All rights reserved.