Evaluation Of Tp-E Interval And Tp-E/Qtc Ratio in Patients With Ischemic Stroke


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ŞEVİK Ö. E., ÇANAKÇI M. E., AY Y., DÖNMEZ E., BALOĞLU KAYA F., KARAKILIÇ M. E., ...Daha Fazla

7th Eurasian Congress on Emergency Medicine& 17th Turkish Congress on Emergency Medicine, Antalya, Türkiye, 25 Kasım 2021, ss.247

  • Yayın Türü: Bildiri / Tam Metin Bildiri
  • Basıldığı Şehir: Antalya
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.247
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

OBJECTIVE: Ischemic stroke is a disease that has strong relations with cardiac arrhythmias, mainly atrial fibrillation (AF). There are many studies on ECG parameters that might help stratify risk factors better. One of them is the time to T wave’s peak amplitude to its end (Tp-e) and the ratio of corrected QT interval (Tp-e/QTc ratio). Current literature suggests that these parameters which show transmural repolarization are linked to cardiac arrhythmias. Our study aimed to investigate Tp-e intervals and Tp-e/QTc ratios of stroke patients and whether these parameters could predict patients’ mortalities and morbidity scales. MATERIAL and METHODS: Information about patients in six months who were hospitalized from Emergency Department to Neurology Department (both ward and ICU) with the diagnosis of ischemic stroke were gathered from hospital database with their ECGs on their specific admission retrospectively. Patients with known or newly diagnosed AF were excluded. Remaining ECGs’ Tp-e intervals and Tp-e/QTc ratios were calculated manually by an Emergency Medicine specialist. Modified Rankin Score (mRs) was used to determine patients’ morbidity and 3 or higher scores were accepted as ‘dependent’. RESULT: A total of 190 patients were included in the study. 55.8% of the patients were male. Median age was 70.0 [IQR: 61.0-77.8]. While 17 patients (8.9%) were treated with alteplase, 26 patients (13.7%) got endovascular intervention. Twenty-four patients were admitted to the ICU and 166 patients were admitted to the ward. Fifteen patients died in hospital in their follow up and the rest could be discharged with a modified Rankin score ranging between 0 and 5. There was no statistically significant relationship found between Tp-e interval and ward/ICU hospitalization, dependency, and mortality (p=0.516, p=0.436 and p=0.864 respectively). Also, Tp-e/QTc ratio was found not to be related to ward/ICU hospitalization, dependency, and mortality (p=0.290, p=0.431 and p=0.765 respectively) CONCLUSION: New studies show that there might be a relation between Tp-e interval and Tp-e/QTc ratio and various conditions such as benign paroxysmal positional vertigo, sickle cell anemia and COVID-19. While larger studies on the topic are needed, our study’s findings suggest that there is no link to these relatively new ECG parameters in terms of morbidity, mortality, or clinical predictability in stroke patients. Keywords: Electrocardiography, Tp-e, QTc, Stroke