Antiprotozoal assessment and phenolic acid profiling of five Fumaria (fumitory) species


ERDOĞAN ORHAN İ., ÖZTÜRK N., ŞENER B.

ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE, cilt.8, sa.4, ss.283-286, 2015 (SCI-Expanded) identifier identifier

Özet

Objective: To explore some Fumaria species which were recorded to be traditionally used against malaria and other protozoal diseases. Methods: Consequently, in the current study. antiprotozoal effect of the ethanol extracts obtained from five Fumaria species (Fumaria densiflora, Fumaria cilicica, Fumaria rostellata, Fumaria kralikii, and Fun:aria parviflora) was investigated against the parasites; Plasmodium falciparum (malaria) and Tryanosoma bruceirhodesiense (human African trypanosomiasis) at 0.81 and 4.85 mu g/mL concentrations. Results: Among them, Fumaria densiflora extract exerted the highest antiplasmodial (93.80%) and antitrypanasomal effect (55.40%). while the ethanol extracts of Fumaria kralikii (43.45%) and Fumaria rostellata (41.65%) showed moderate activity against Plasmodium falciparum. Besides, phenolic acid contents of the extracts were analyzed using high performance liquid chromatography (HPLC) and trans-cinnamic (4.32 mg/g) and caffeic (3.71 mg/g) acids were found to be the dominant phenolic acids in Fumaria densiflora. Conclusions: According to our results. Fumaria densiflora deserve further study for its promising antiprotozoal activity.