Some pyrrole substituted aryl pyridazinone and phthalazinone derivatives and their antihypertensive activities

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Demirayak S., Karaburun A., Beis R.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol.39, no.12, pp.1089-1095, 2004 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 39 Issue: 12
• Publication Date: 2004
• Doi Number: 10.1016/j.ejmech.2004.09.005
• Journal Name: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.1089-1095
• Eskisehir Osmangazi University Affiliated: No

Abstract

In this work, some 2-nonsubstituted/2-methyl-/2-(2-acetyloxyethyl)-6-[4-(substituted pyrrol-1-yl)phenyl]-4,5-dihydro-3(2H)-pyridazinone. derivatives and 2-nonsubstituted/2-methyl- 4-[4-(substituted pyrrol-1-yl)phenyl]-1(2H)-phthalazinone derivatives were synthesised by reacting hexan-2.5-dion or 1-aryl-3-carbethoxypent-1,4-diones with corresponding 2-substituted/non substituted 6-(4'-aminophenyl)-4,5-dihydro-3(2H)-pyridazinone or 2-substituted/nonsubstituted-4-(4'-aminophenyl)-(2H)-phthalazinone under Paal-Knorr pyrrole synthesis conditions. The antihypertensive activities of the compounds were examined both in vitro and in vivo. Some pyridazinone derivatives showed appreciable activity. (C) 2004 Elsevier SAS. All rights reserved.