Some pyrrole substituted aryl pyridazinone and phthalazinone derivatives and their antihypertensive activities

Demirayak S., Karaburun A., Beis R.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, cilt.39, sa.12, ss.1089-1095, 2004 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 39 Sayı: 12
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1016/j.ejmech.2004.09.005
  • Dergi Adı: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1089-1095
  • Eskişehir Osmangazi Üniversitesi Adresli: Hayır

Özet

In this work, some 2-nonsubstituted/2-methyl-/2-(2-acetyloxyethyl)-6-[4-(substituted pyrrol-1-yl)phenyl]-4,5-dihydro-3(2H)-pyridazinone. derivatives and 2-nonsubstituted/2-methyl- 4-[4-(substituted pyrrol-1-yl)phenyl]-1(2H)-phthalazinone derivatives were synthesised by reacting hexan-2.5-dion or 1-aryl-3-carbethoxypent-1,4-diones with corresponding 2-substituted/non substituted 6-(4'-aminophenyl)-4,5-dihydro-3(2H)-pyridazinone or 2-substituted/nonsubstituted-4-(4'-aminophenyl)-(2H)-phthalazinone under Paal-Knorr pyrrole synthesis conditions. The antihypertensive activities of the compounds were examined both in vitro and in vivo. Some pyridazinone derivatives showed appreciable activity. (C) 2004 Elsevier SAS. All rights reserved.