OXYGEN-FREE RADICALS IMPAIR FRACTURE-HEALING IN RATS

GOKTURK E., TURGUT A., BAYCU C., GUNAL I., SEBER S., GULBAS Z.

ACTA ORTHOPAEDICA SCANDINAVICA, vol.66, no.5, pp.473-475, 1995 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 66 Issue: 5
  • Publication Date: 1995
  • Doi Number: 10.3109/17453679508995590
  • Journal Name: ACTA ORTHOPAEDICA SCANDINAVICA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, SportDiscus
  • Page Numbers: pp.473-475
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

We studied the effect of oxygen-free radicals on fracture healing. 30 male rats were divided into 2 groups: 15 rats were given saline 5 mL/kg i.p. (control group) and 15 were given zymosan 100 mg/kg i.p. to induce oxygen-free radicals through stimulation of NADPH oxidase in polymorphonuclear leucocytes. 1 hour later, the right forelimbs of the rats were broken by light manual compression. These treatments were given once a day until the fifth postfracture day. All rats were killed on day 22, and histological sections of the radius and ulna were examined without knowledge of the treatment given. The administration of zymosan impaired the fracture healing and therefore oxygen-free radicals appear to play an important role in fracture healing.