Relationship between adipocytokines and cardiovascular risk factors in patients with type 2 diabetes mellitus

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USLU S., Kebapci N., KARA M., BAL C.

EXPERIMENTAL AND THERAPEUTIC MEDICINE, cilt.4, sa.1, ss.113-120, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 4 Sayı: 1
  • Basım Tarihi: 2012
  • Doi Numarası: 10.3892/etm.2012.557
  • Dergi Adı: EXPERIMENTAL AND THERAPEUTIC MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.113-120
  • Anahtar Kelimeler: adipocytokines, cardiovascular risk markers, type 2 diabetes mellitus, INSULIN-RESISTANCE, ASYMMETRIC DIMETHYLARGININE, HOMOCYSTEINE LEVELS, METABOLIC SYNDROME, ADIPONECTIN LEVELS, JAPANESE PATIENTS, OXIDATIVE STRESS, SERUM VISFATIN, LEPTIN, DISEASE
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

The aim of this study was to explore the relationship between serum profiles of adiponectin, leptin, resistin and visfatin and traditional and non-traditional cardiovascular risk factors in patients with type 2 diabetes mellitus (T2DM). A total of 85 patients with T2DM and 30 non-diabetic controls were enrolled in the study. Levels of adipocytokines (adiponectin, leptin, resistin and visfatin), lipids (total cholesterol, triglycerides), lipoproteins [HDL-cholesterol, LDL-cholesterol, lipoprotein (a)], apolipoproteins (Apo-A1 and Apo-B), non-traditional cardiovascular risk markers [asymmetric dimethylarginine (ADMA), homocysteine] and the inflammatory marker hs-CRP were measured, and anthropometric variables were determined. Serum adiponectin levels were decreased and leptin, resistin and visfatin levels were increased in T2DM patients compared to controls. They were associated with obesity (BM I), insulin resistance (HOMA-IR) and various markers of glucose/lipid profile, inflammation and endothelial dysfunction markers. These results suggest that decreased serum adiponectin and increased leptin, resistin and visfatin levels in T2DM may be novel biochemical risk factors for cardiovascular complications.