Anticholinesterase activity screening of some novel dithiocarbamate derivatives including piperidine and piperazine moieties


LEVENT S., ÇEVİK U. A. , SAĞLIK B. N. , ÖZKAY Y., CAN Ö. D. , DEMİR ÖZKAY Ü., ...More

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, vol.192, no.4, pp.469-474, 2017 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 192 Issue: 4
  • Publication Date: 2017
  • Doi Number: 10.1080/10426507.2016.1259228
  • Title of Journal : PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
  • Page Numbers: pp.469-474

Abstract

The present study was undertaken to synthesize some novel lipophilic piperazine and piperidinedithiocarbamates and investigate their inhibitory potencies against cholinesterase enzymes. In the synthetic studies, 44 new compounds were isolated. The structures of the synthesized compounds were confirmed by spectroscopic analyses. Enzymatic studies were carried out using modified Ellman's assay against Acetyl cholinesterase (AChE) and Butrylcholinesterase (BChE) enzymes, and it was observed that some of the compounds selectively inhibit AChE. Theoretical ADME predictions were calculated for selected compounds in the series. Enzyme kinetics and molecular docking studies were performed for the most active compound C41 and nature of inhibition and interactions between enzyme and ligand were explained.