Synthesis and physical gels of pH- and thermo-responsive tertiary amine methacrylate based ABA triblock copolymers and drug release studies

Taktak F. F., BÜTÜN V.

POLYMER, cilt.51, sa.16, ss.3618-3626, 2010 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51 Sayı: 16
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.polymer.2010.06.010
  • Dergi Adı: POLYMER
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.3618-3626
  • Anahtar Kelimeler: ABA triblock copolymer, Hydrogels, Drug release, GROUP-TRANSFER POLYMERIZATION, AQUEOUS-SOLUTION PROPERTIES, THERMOREVERSIBLE GELATION, WEAK POLYELECTROLYTES, RESPONSIVE POLYMERS, SENSITIVE HYDROGELS, IN-VITRO, DELIVERY, TEMPERATURE, BEHAVIOR
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

A series of novel pH-responsive ABA triblock copolymer gelators have been synthesized by using poly[2-(diisopropylamino)ethyl methacrylate] (PDPA) as the A block and poly[2-(dimethylamino)ethyl methacrylate] (PDMA) as the B block via group transfer polymerization. While the PDPA-b-PDMA-b-PDPA triblock copolymers are molecularly soluble in acidic aqueous media due to protonation of all tertiary amine groups, they formed either gels by the chain-end hydrophobic interactions with relatively high polymer concentration (10 wt%) or near monodisperse "flower" micelles with low polymer concentration at neutral and basic aqueous solutions. The hydrophobic model drug release was studied in a sustained manner from the gels at pH 7.4 by varying the polymer concentration, the polymer molecular weight and the temperature of the medium. Preliminary studies indicate that both slow, sustained release and fast, triggered release of a model hydrophobic drug, dipyridamole, can be achieved by tuning the solution pH, polymer concentration, polymer molecular weight and temperature of the gel. (C) 2010 Elsevier Ltd. All rights reserved.