Synthesis and Antimicrobial Activity of Some New N-(1H-benzimidazol-2yl)-2-mercaptoacetamide Derivatives

Evren A. E., Tekinkoca S., YURTTAŞ L.

LETTERS IN DRUG DESIGN & DISCOVERY, vol.15, no.2, pp.154-159, 2018 (SCI-Expanded) identifier identifier


Background: Due to multi-drug, extended-drug, and pandrug resistance phenotypes, bacterial resistance to antibiotics and fungal infections are a general health issue. Particulary, increase of fungal infections due to secondary cause of human diseases have been observed. An extensive variety of benzimidazole derivatives have been characterized for their chemotherapeutic significance. Benzimidazole derivatives have received important attention because of pharmacological significance during current years, especially antimicrobial, anti-fungal, antitubercular, antioxidant, anti-Alzheimer's disease and antihypertension activities.