Boron Prevents Oral Acrylamide Damage in Bone Marrow and Hematologic Parameters of Wistar Rats

Selimoğlu F., Cengiz M., Vejselova Sezer C., AYHANCİ A., GÜR F., Yıldırım Ö., ...Daha Fazla

Biological Trace Element Research, cilt.203, sa.11, ss.5882-5889, 2025 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 203 Sayı: 11
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1007/s12011-025-04610-4
  • Dergi Adı: Biological Trace Element Research
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aqualine, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, Food Science & Technology Abstracts, Pollution Abstracts, Veterinary Science Database
  • Sayfa Sayıları: ss.5882-5889
  • Anahtar Kelimeler: Acrylamide, Boron, Hematologic toxicity, Myelotoxicity, Rats
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

The purpose of this study is to measure the effects of acrylamide (AA) on bone marrow and blood and the protective efficacy of boric acid (B) in rats. The animals were divided into five groups: control, B, low-dose B + AA, and high-dose B + AA. After the 15 th day of the experiment, their blood and bone marrow were harvested to be kept for hematological analyses. While white blood cells (WBC) increased following the administration of AA, bodyweight, red blood cells, platelets, hemoglobin, hematocrit, and bone marrow nucleated cell counts significantly decreased in number. Conversely, bodyweight and all these hematological parameters significantly increased apart from WBC in the B + AA groups AA when compared to the control. However, high-dose B was more effective than low-dose B in preventing AA-induced bone marrow and hematological damage. The present study suggests that B treatment could help protect bone marrow and hematological parameters against AA-induced toxicity.