Benign clear cell adenofibroma of the ovary: A case report with literature review

Pasaoglu O., Ciftci E., Tel N., Ozalp S., Acikalin M. F.

Gynecologic and Obstetric Investigation, vol.64, no.1, pp.36-39, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 64 Issue: 1
  • Publication Date: 2007
  • Doi Number: 10.1159/000098425
  • Journal Name: Gynecologic and Obstetric Investigation
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.36-39
  • Keywords: clear cell tumor, adenofibroma, clear cell, ovary
  • Eskisehir Osmangazi University Affiliated: Yes


Most clear cell neoplasms of the ovaries are carcinomas; benign and borderline clear cell tumors are uncommon. To date, only 12 cases of benign clear cell adenofibroma have been reported in the literature. Here we report a case of benign clear cell adenofibroma of the left ovary in a 51-year-old postmenopausal woman. Histological examination revealed widely spaced simple glands embedded in a dense fibrous stroma. The glands were lined by one to two layers of cells with abundant clear cytoplasm. The nuclei were bland and uniform in size and shape. There was minimal cytologic atypia in some areas. In this article we discussed the criteria for the diagnosis of benign and borderline clear cell adenofibromas and reviewed the literature. Copyright © 2007 S. Karger AG.