Epileptic Activity in a Patient with Serum Anti-GAD Antibody-positive Limbic Encephalitis

Ozozen Ayas Z., Kotan D.

EPILEPSI, vol.26, no.1, pp.45-48, 2020 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 1
  • Publication Date: 2020
  • Doi Number: 10.14744/epilepsi.2019.16870
  • Journal Name: EPILEPSI
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.45-48
  • Eskisehir Osmangazi University Affiliated: Yes


Limbic encephalopathy (LE) is an entity, which may present with memory loss, seizure, psychiatric symptoms and is usually accompanied by neuro-radiology imaging findings. In recent years, antibody tests that can be studied in detail have gained importance as markers. Glutamic acid decarboxylase antibody (GAD-Ab) has been reported to be mainly responsible for non-paraneoplastic syndromes. GAD-Ab positivity is predominantly seen in young adult females and temporal lobe epilepsy. Patients with GAD-Ab positive have been reported to respond well or partial to immunotherapy. In this article, we report a 38-year-old woman presenting with seizure and diagnosed with limbic encephalitis who had magnetic resonance imaging and electroencephalograhy findings accompanied by serum GAD-ab positivity was reported. GAD-Ab is considered to play an important role in the prognosis of LE and the other neurological syndromes and should be investigated further.